A new improved RP-HPLC method for assay of rosuvastatin calcium in tablets
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چکیده
منابع مشابه
A New Improved RP-HPLC Method for Assay of Rosuvastatin Calcium in Tablets
A reliable and sensitive isocratic stability indicating RP-HPLC method has been developed and validated for assay of rosuvastatin calcium in tablets and for determination of content uniformity. An isocratic separation of rosuvastatin calcium was achieved on YMC C8, 150×4.6 mm i.d., 5 μm particle size columns with a flow rate of 1.5 ml/min and using a photodiode array detector to monitor the elu...
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A rapid, specific, sensitive and simple high performance liquid chromatography was developed for simultaneous estimation of Rosuvastatin Calcium and Fenofibrate in tablet formulation. The separation was achieved by phenomenex C18
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The present study describes the development of a validated RP-HPLC method for the determination of 5-fluorouracil in presence of its degradation products or other pharmaceutical excipients. Stress studies were performed on 5-fluorouracil and it was found that it degrades sufficiently in alkaline conditions, while negligible degradation was observed in acidic, neutral, oxidative and photolytic c...
متن کاملDevelopment and Validation of Rp-hplc Method for the Estimation of Rosuvastatin Calcium in Bulk and Tablet Dosage Form
A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Rosuvastatin in pure and pharmaceutical formulations. Method was carried on Symmetry C18 column (100 X 4.6 mm i.d., particle size 3.5um,ACE) using acetontrile: phosphate buffer as mobile phase in the ratio of 60:40v/v/. The detection was carried out at 243nm using Waters (2659) UV-Visible d...
متن کاملApplication of RP-HPLC for Determination of the Dissociation Constants of Rosuvastatin Calcium
Rosuvastatin calcium (RC), is a member of a drug group called statins which are used to lower hypercholesterolemia and to prevent cardiovascular diseases, a synthetic lipid-lowering agent, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) which is a catalyst in the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis in liver1, 2. The empirical...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2010
ISSN: 0250-474X
DOI: 10.4103/0250-474x.78526